NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal.

نویسندگان

  • Tatsuya Tada
  • Tohru Miyoshi-Akiyama
  • Rajan K Dahal
  • Manoj K Sah
  • Hiroshi Ohara
  • Teruo Kirikae
  • Bharat M Pokhrel
چکیده

A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 5  شماره 

صفحات  -

تاریخ انتشار 2013